REPROGRAMIRANJE INFLAMATORNOG MIKROOKRUŽENJA U SINOVIJALNIM ZGLOBOVIMA SA OSTEOARTRITISOM POMOĆU ĆELIJSKE TERAPIJE – SAŽET PREGLED TISSUEGENE-C

Sažetak

Osteoarthritis (OA) remains the most prevalent chronic joint disease globally [1], characterized by progressive articular cartilage degeneration, synovial inflammation, and debilitating pain [2,3]. Despite its profound socioeconomic impact, therapeutic strategies have historically remained limited to symptom management, such as non-steroidal anti-inflammatory drugs (NSAIDs) and, eventually, total joint re placement [4,5]. The current medical landscape urgently demands disease-modifying therapies that can halt progression, repair tissue, and address the multi faceted pathology of OA, which is now understood to be a complex mechano-inflammatory disease [6,7]…