OD SMERNICA ZA LEČENJE I IZJAVA O KONSENZUSU DO PRIMENE U STVARNOM SVETU − TRANSFORMISANJE LEČENJA OSTEOARTRITISA FENOTIPSKOM STRATIFIKACIJOM I MULTIDISCIPLINARNIM PRISTUPOM

Introduction

Osteoarthritis (OA) is the most prevalent and disabling form of arthritis worldwide. The current OA management landscape is characterized by a significant discordance between guideline recommendations and their implementation in primary care. Although numerous clinical practice guidelines exist, they often contain subtle inconsistencies and, more importantly, fail to adequately account for the substantial heterogeneity and multimorbidity that characterize the OA population. Phenotypic heterogeneity in OA manifests across multiple do mains, including structural, inflammatory, metabolic, and pain-related pathways. This diversity is primary key reason why single-agent or unimodal treatments frequently fail to provide satisfactory out comes, contributing to patient dissatisfaction and placing and increasing and unsustainable burden on primary healthcare systems …