IZOFORME KONSTANTE BETA LANCA T-ĆELIJSKOG RECEPTORA – NOVA PARADIGMA U DIJAGNOZI T-ĆELIJSKIH NEOPLAZMI

The adaptive immune system has evolved to recognize as many foreign antigens as possible. The diversity of antigen recognition abilities by B and T- cells is achieved through combinatorial diversity and “imprecision” diversity. The former is the result of functional antigen-recognizing receptors (immunoglobulin receptor (Ig) and T-cell receptor (TCR)) being modular molecules. There are many variable segments with high sequence variability (V-regions of heavy and light chains of immunoglobulin receptor and alpha-through-delta chains of TCR) and few constant segments (C-regions, in translated protein close to/embedded in the membrane of B and T-lymphocytes). RAG-mediated DNA recombination during the development of B and T-cells in the bone mar row and thymus, respectively, combines variable and constant regions (as well as diversity-D and junction J segments) into recombined DNA ready for transcription and translation of the message into a functional surface receptor protein …